Figure 4 Elevated Plus Maze

4.1 Statistical Analyses

One-way ANOVA on time spent in the open arm indicated a significant effect of group (F(1,57) = 4.78, p = 0.03).

## 
##  One-way analysis of means
## 
## data:  Open_Tm and TMT
## F = 4.7778, num df = 1, denom df = 57, p-value = 0.03295

.y.	group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
Open_Tm	CTL	Saline	18	20	0.0428	*	0.128	ns
Open_Tm	CTL	Nor-BNI	18	21	0.0889	ns	0.267	ns
Open_Tm	Saline	Nor-BNI	20	21	0.7080	ns	1.000	ns

One-way ANOVA on time the number of entries into the open arm indicated a significant effect of group (F(1,57) = 14.78, p < 0.001)

## 
##  One-way analysis of means
## 
## data:  Open_Freq and TMT
## F = 14.782, num df = 1, denom df = 57, p-value = 0.0003064

## 
##  One-way analysis of means
## 
## data:  Open_Tm and TMT
## F = 4.7778, num df = 1, denom df = 57, p-value = 0.03295

.y.	group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
Open_Freq	CTL	Saline	18	20	0.004870	**	0.01460	*
Open_Freq	CTL	Nor-BNI	18	21	0.000403	***	0.00121	**
Open_Freq	Saline	Nor-BNI	20	21	0.415000	ns	1.00000	ns

Follow-up pairwise comparisons indicated that CTL mice made more entries into the open arms than TMT+Saline (p = 0.005) or TMT+NorBNI (p < 0.001) mice, and that there was no effect of NorBNI treatment among TMT-exposed mice (p = 0.41)

There were no differences in time spent in the closed arms or number of enteries into the closed arms.

## 
##  One-way analysis of means
## 
## data:  Closed_Tm and TMT
## F = 1.2163, num df = 1, denom df = 57, p-value = 0.2747

## 
##  One-way analysis of means
## 
## data:  Open_Tm and TMT
## F = 4.7778, num df = 1, denom df = 57, p-value = 0.03295

.y.	group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
Closed_Tm	CTL	Saline	18	20	0.677	ns	1.000	ns
Closed_Tm	CTL	Nor-BNI	18	21	0.141	ns	0.422	ns
Closed_Tm	Saline	Nor-BNI	20	21	0.276	ns	0.827	ns

## 
##  One-way analysis of means
## 
## data:  Closed_Freq and TMT
## F = 1.691, num df = 1, denom df = 57, p-value = 0.1987

## 
##  One-way analysis of means
## 
## data:  Open_Tm and TMT
## F = 4.7778, num df = 1, denom df = 57, p-value = 0.03295

.y.	group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
Closed_Freq	CTL	Saline	18	20	0.0949	ns	0.285	ns
Closed_Freq	CTL	Nor-BNI	18	21	0.5480	ns	1.000	ns
Closed_Freq	Saline	Nor-BNI	20	21	0.2570	ns	0.771	ns

## 
##  One-way analysis of means
## 
## data:  exp_index and TMT
## F = 11.698, num df = 1, denom df = 57, p-value = 0.001163

## 
##  One-way analysis of means
## 
## data:  Open_Tm and TMT
## F = 4.7778, num df = 1, denom df = 57, p-value = 0.03295

.y.	group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
exp_index	CTL	Saline	18	20	0.00474	**	0.0142	*
exp_index	CTL	Nor-BNI	18	21	0.00411	**	0.0123	*
exp_index	Saline	Nor-BNI	20	21	0.98600	ns	1.0000	ns